As many of you know, all I do is treat Hashimoto’s and over the last 4 years I have worked and spoken with over 2,000 people with Hashimoto’s.
Most of these conversations have happened during my consultations. In these, people share with me their struggles and I offer advice that helps them right away.
By far, the most common theme of these conversations is that they have normal lab results (this usually means TSH and T4 – to learn more about what are better tests to order read this post) and yet they have all the common hypothyroid symptoms.
In other words, they are fatigued, they have brain fog and memory issues, their hair is falling out, the may have depression, constipation, difficulty sleeping and muscle weakness or joint pain and more.
While researchers sometimes claim that this is rare, clinical experience and empirical data prove otherwise. I put this question to my Facebook support group on 2 occasions and over 300 people responded that they have some or all of the symptoms above and “normal” lab test results.
This situation isn’t rare, it’s very common.
And the vast majority of these people are taking some type of thyroid replacement hormone. The prescriptions vary from Synthroid to Armour to Levothyroxine and sometimes there’s some Cytomel thrown in or they’re taking Naturethroid or Tyrosint.
But often, regardless of the prescription or the dosage, they still have all the hypothyroid symptoms. And some people are over-medicated so they have hyper symptoms, as well. Like, palpitations, insomnia, tachycardia, anxiety, etc.
And after a while you have to ask: What is going on here?
It’s the same story over and over again. The medications are different, the constellation of symptoms are different, but the basic pattern is the same.
People are getting plenty of thyroid hormone, but it’s not getting into their cells and having the effect it is supposed to.
If it were, they’d have no hypothyroid symptoms. But virtually everyone does have hypothyroid symptoms.
In this post we examine why thyroid hormone conversion doesn’t happen the way it’s supposed to and what to do about it.
Let’s Review the Physiology
First of all, let’s look at basic physiology. In the body, normally, the thyroid is signaled by the pituitary with TSH (Thyroid Stimulating Hormone). The purpose of this is to goose the thyroid into producing more thyroid hormone.
This occurs because of signals from the body that it needs more. If it’s cold or you need your heart rate to increase, or your metabolism to rev up or you needs to get things moving for sex, etc.
When this happens the thyroid releases T4 (about 97%) and a little bit of T3 (do the math – yup, 3%).
And this is the basic premise of thyroid replacement hormones like Synthroid. It’s synthetic T4. The theory is that you just give it to the patient and tell them to call you in 6 months. An everything should be hunky dory.
And the reason it doesn’t work is that thyroid hormone must be converted from T4 into T3 in order for the body to utilize it. This conversion happens differently in different parts of the body.
The problem with TSH only testing to determine thyroid hormone levels in the entire body is that the pituitary, which releases TSH, converts thyroid hormone differently than the rest of the body.
This is why you often see normal TSH with lots of hypothyroid symptoms.
Many doctors, somehow, are ignorant of this fact and instead of truly understanding what is happening physiologically, blame the patient for having symptoms when their lab tests say that they should be fine.
There is an enzyme that is largely responsible for thyroid hormone conversion. It is called 5′ deodinase. And it actually comes in 3 forms: deodinase type I (D1), deodinase type II (D2)and deodinase type III (D3).
D1 converts inactive T4 to active T3 throughout the body. In the pituitary, D2 controls this conversion. These two forms behave very differently and are affected by different things.
D1 is suppressed and down-regulated (which means it decreases T4 to T3 conversion and increases reverse T3 levels) in response to stress (both physiologic and emotional), depression, dieting, weight gain and leptin resistance, insulin resistance, obesity and diabetes, inflammation from autoimmune disease or systemic illness, chronic fatigue syndrome and fibromyalgia, chronic pain, and exposure to toxins and plastics.
What did we just describe? Your average Hashimoto’s patient living in the modern world! Most people with Hashimoto’s have the majority of conditions mentioned above.
In addition, D1 activity is also lower in females, making women more prone to tissue or functional hypothyroidism.
Sound familiar? Normal lab results but hypothyroidism at the cellular level.
And when you have these conditions, there are reduced tissue levels of active thyroid hormone in all tissues except the pituitary because D2 does not behave like this, at all.
D2 is 1,000 times more efficient at converting T4 to T3 than D1 in the rest of the body. And it isn’t suppressed and down regulated by any of the things we mentioned.
So TSH is within normal range because the pituitary is getting plenty of thyroid hormone, but the rest of the body is hurtin’ for certain.
D3 converts T4 into reverse T3. There is none of it in the pituitary. D3 also competes with D1. T4 can go either way. It can be converted to T3 which the body can use or into reverse T3 which is not active.
And reverse T3 blocks the effect of T3. It blocks T3 from binding to receptors and when this happens it doesn’t work. So your metabolism slows, and D1 is suppressed so it can’t do it’s job and convert T3 to T4. And D3 blocks T3 and T4 from getting absorbed into cells.
So the result is you have low T3 levels in the cells of your body and you get all the hypothyroid symptoms.
Like most things related to Hashimoto’s the solution is not simple and it requires a multi-prong approach.
As I have said and written many times, Hashimoto’s is way more than a thyroid problem and way more than a thyroid and autoimmune problem. It is a multi-system disorder that can only be healed using a multi-system approach.
Nowhere is this more evident than in trying to fix poor thyroid hormone conversion.
There are 5 important areas that need to be assessed and addressed if you want better conversion of T4 to T3.
Let’s break it down:
1. Liver Detoxification and Other Metabolic Pathways
2. Increasing T3 and Lowering Reverse T3 Levels
3. The Gut and Thyroid Hormone Conversion
4. Adrenal Stress Can Cause Lower T3 and Higher Reverse T3
5. Systemic Inflammation Lowers T3
And as a bonus we’ll look at key nutrients that support better thyroid hormone conversion.
In the liver D1 is involved in converting T4 into T3 and selenium is an important part of this process. Reverse T3 is also broken down there.
So having enough selenium is essential. (It is recommend to take from 200 to 400 mcg. (micrograms) per day. Make sure you do not take selenium supplements that contain dairy or gluten based fillers.)
Other important factors that can prevent T4 to T3 conversion include stress (both emotional and physiological), poor nutrition, chronic illness and exposure to heavy metals like cadmium, mercury and lead.
Another important factor is lipid peroxidation and antioxidants in the liver. One of the most important in helping the body deal with the damage caused by these heavy metals and to nourish antioxidant enzyme systems is glutathione.
The best form to take orally is S-Acetyl-L-Glutathione. It can also be taken in liposomal cream form or in an IV.
In addition, there are 2 metabolic pathways in the liver that can have an impact on thyroid hormones. One such pathway is the glucoronidation pathway. This pathway is supported by B vitamins, magnesium, and glysine.
The second is sulfation. Sulfation involves binding things partially broken down in the liver with sulfur containing compounds. It is one of the major detoxification pathways for neurotransmitters, toxins, and hormones (like thyroid hormones).
Vitamin B6 and magnesium are important for sulfur amino acid metabolism, as are foods containing sulfur such as: eggs, meat, poultry, nuts and legumes. (Eggs, nuts and legumes might be a problem if you are on the Autoimmune diet.)
Lowering reverse T3 levels and increasing T3 levels is not a simple thing. There are so many variables and other factors that may hinder this process that it’s hard to offer general things that will help.
To really do this properly, one must be tested, evaluated and treated according to what results, symptoms and patterns present themselves.
That being said, let’s look at some general things that may help.
Glucoronidation, mentioned above, has been shown to degrade reverse T3.
The addition of T3 to your thyroid replacement hormone regimen may also be helpful. There are those in the thyroid community that strongly advocate T3 only treatment. Some suggest doing with natural cortisol rhythms, some with time released T3 and others with slow and deliberate increases in T3 therapy.
This may or may not work and what they fail to say is that T3 can also be toxic to the liver in high doses. Again, proper assessment and treatment is required to determine if this course of action is a good idea for you.
Elevations in cortisol, catecholamines, and some cytokines (IL-6, TNF-a, and IFN-a), and low serum albumin levels have also been associated with low T3 syndrome.
Gut bacteria is important for converting T4 into T3.
About 20 percent of T4 is converted to T3 in the GI tract, in the forms of T3 sulfate (T3S) and triidothyroacetic acid (T3AC). The conversion of T3S and T3AC into active T3 requires an enzyme called intestinal sulfatase.
Intestinal sulfatase comes from healthy gut bacteria. (Sulfur is an important nutrient for this, as well).
When you have an imbalance between good and bad bacteria in the gut, this may significantly reduce the conversion of T3S and T3AC to T3. This is one reason why people with poor gut function may have thyroid symptoms but normal lab results.
Inflammation in the gut also reduces T3 by raising cortisol. Cortisol decreases active T3 levels while increasing levels of inactive T3.
Studies have also shown that cell walls of intestinal bacteria, called lipopolysaccharides (LPS), negatively effect thyroid metabolism in several important ways.
LPS:
• reduce thyroid hormone levels;
• dull thyroid hormone receptor sites;
• increase amounts of reverse T3;
• decrease TSH; and
• promote autoimmune thyroid disease (AITD).
With stress, cortisol levels often go up. The increased cortisol levels contribute to this disconnect in the body between the TSH and peripheral tissue T3 levels.
Stress reduces T3 levels in the tissues and increases reverse T3 and this results in tissue hypothyroidism and potential weight gain, fatigue, and depression.
This vicious cycle of weight gain, fatigue, and depression that is associated with stress may be prevented with supplementation with timed-released T3 according to some studies.
The reduced immunity from chronic stress has also been thought to be due to excess cortisol production; but the associated reduction in tissue thyroid levels are shown to play a larger role in the decreased immunity seen with stress.
As with stress, treatment with prednisone or other glucocorticoid will suppress D1 and stimulate D3, reducing T4 to T3 conversion and increasing T4 to reverse T3, causing a relative tissue hypothyroidism that is not detected by TSH testing.
This low cellular thyroid level certainly contributes to the weight gain and other associated side-effects with such treatment. Thus, in stressed patients or those treated with corticosteroids, there are reduced tissue T3 levels that are not reflected by the TSH level, making the TSH an inappropriate marker for tissue levels of T3.
So making sure that you have proper levels of DHEA and cortisol is very important.
As is changing the things in your life that cause you stress. With Hashimoto’s we have emptied our stress savings accounts. We have so much physiologic stress that added emotional stress is incredibly destructive. And one area, in particular, is in the impact of stress on tissue levels of T3.
Hashimoto’s is, at it’s root, a disease of inflammation. And research has found that the inflammatory immune cells (cytokines) and proteins like IL-1, Il-6, C-reactive protein (CRP), and TNF-alpha will significantly decrease D1 activity and reduce tissue T3 levels. Any person with an inflammatory condition – Hashimoto’s – will have a decreased T4 to T3 conversion in the body and a relative tissue hypothyroidism.
These immune proteins will, however, increase the activity of D2 and suppress the TSH despite reduced peripheral T3 levels; again, making a normal TSH an unreliable indicator of normal tissue thyroid levels.
There is also a direct inverse correlation between CRP and reduced tissue T3, so individuals with elevated CRP (greater than 3 mg/l) or other inflammatory cytokines may have a significant reduction in cellular T3 levels.
The suppression of T3 levels inside the cells is linked with the degree of elevation of CRP, despite serum thyroid tests being “normal”.
So, if any inflammation is present, the body will have lower T3 levels in the cells and this can impact function; but the pituitary will have increased levels of T3, resulting in a lowering of the TSH so that, once again test results appear normal. (Have I made this point enough times?)
This really emphasizes the importance of anti-inflammatory strategies to improve T3 levels in the tissues. Anti-inflammatories like Turmeric, ginger, resveratrol, glutathione, and Vitamin D are all helpful.
Sometimes these are needed in rather high dosages.
Eliminating foods that cause inflammation is also absolutely critical: gluten, dairy, soy, sugar, alcohol, processed foods, pesticides and chemical additives should all be strictly eliminated.
The Autoimmune Paleo approach is an excellent diet for reducing systemic inflammation and increasing tissue T3 levels.
Commiphora muku guggulu (Myrrh resin) Guggul produces a resinous sap known as gum guggul. The extract of this gum, called gugulipid, guggulipid or guglipid, has been used in Ayurvedic medicine, a for nearly 3,000 years in India. The active ingredient in the extract is the steroid guggulsterone. This has been shown to stimulate healthy synthesis of T3.
Selenium is a major cofactor for the enzyme 5′ deiodinase which is responsible for converting T4 into T3 as well as degrading reverse T3.
Low zinc status has been shown to compromise T3 production. Zinc can improve thyroid hormone production and play a role in reducing antibodies.
Lipid peroxidation and antioxidant enzyme systems have been shown to play a profound role peripheral thyroid hormone conversion. Glutathione is extremely effective in supporting peroxidation.
Lastly, it is essential to work with someone who understands the complexity of this situation and who can evaluate what is going on properly and who can determine which course of action and combination of things may be best for you.
http://nahypothyroidism.org/deiodinases/
http://www.aaqm.org/Downloads/doc-qmuAUG08.pdf
http://www.chiro.org/nutrition/FULL/Peripheral_Metabolism_of_Thyroid.html
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One of my favorite organizations, the Environmental Working Group, released their 2014 list of produce with highest amount of pesticides.
This is a real concern for those of us with Hashimoto’s and hypothyroidism because studies have linked pesticide concentrations with a significant increase in thyroid disease.
They found an association of organochlorines and fungicides with hypothyroidism. And a 12.5% higher increase in thyroid disease than in the general population.
According to the study “Exposure to these classes of pesticides and thyroid dysfunction is plausible given that the main effects of these compounds are thought to be elevation of TSH levels and reduction of circulating thyroid hormone (T3 and T4).”
An Apple A Day Doesn’t Keep The Doctor Away Anymore
Nonorganic apples once again topped The EWG’s Shopper’s Guide to Pesticides in Produce report, making it the fourth year in a row that the fruit that has the reputation of keeping the doctor away, may now be having the opposite effect thanks to better living through chemistry.
Kale, collard greens, and hot peppers were frequently contaminated with insecticides that are particularly toxic to human health, prompting their “Dirty Dozen Plus” status.
The moral of the story? Grow your own in an organic garden and/or buy organic at your local farmer’s market.
1. Apples
2. Strawberries
3. Grapes
4. Celery
5. Peaches
6. Spinach
7. Sweet Bell Peppers
8. Nectarines (Imported)
9. Cucumbers
10. Cherry Tomatoes
11. Snap Peas (Imported)
12. Potatoes
+ Hot Peppers
+ Kale/Collard Greens
It’s not all bad news! This produce contained the lowest pesticide levels.
1. Avocados
2. Sweet Corn
3. Pineapples
4. Cabbage
5. Sweet Peas (Frozen)
6. Onions
7. Asparagus
8. Mangoes
9. Papayas
10. Kiwi
11. Eggplant
12. Grapefruit
13. Cantaloupe
14. Cauliflower
15. Sweet Potatoes
One of the biggest challenges about living with Hashimoto’s is that there can be many set backs.
And if you do not have the ability to bounce back quickly and be resilient, then this may compound your suffering.
Because if you have multiple setbacks, one after the other, and you are still having trouble getting over the first, then you can become mired in gloom, despair and defeat.
One of the best ways to develop resilience is to practice mindfulness and detachment. The more you strengthen your detachment muscles, the easier it is to bounce back.
Detachment allows you to view your emotions from a bit of a distance.
This way you can see that feelings are not facts and emotions are not emergencies. They are just feelings and emotions and they come and go.
And you have a choice about how much importance you are going to give them. It’s all about your perception of them.
A great practice for developing detachment is meditation. Simply sitting, breathing and observing your thoughts.
Even as little as 5 minutes per day can help you develop the ability to observe your mind.
And as you watch it, you will observe thoughts and emotions rush in. Instead of holding onto them, return to your breath or to observing something in your physical body and let those thoughts and emotions go.
It can be challenging at first, but it gets easier.
And once you get a glimpse of the world outside of attachment to these feelings, thoughts and emotions you realize what a prisoner you can be to them.
Getting some degree of freedom from them can have a big impact on our ability to heal.
Sit, breathe and let go.
Please share with us your thoughts, experiences or tricks for finding detachment.
Did you know that low thyroid function is often caused by some other condition first, and often adrenal gland stress is the culprit?
Chronic adrenal stress can:
* Affect communication between the brain and glands that produce hormones. The hypothalamus and pituitary gland are the directors of hormone production and chronic adrenal stress can mess up communication with the thyroid.
* Increase thyroid binding activity, keeping thyroid hormones from getting absorbed by the cells of the body.
* Interfere with the conversion of T4 to active forms of T3 that the body can use.
* Affect detoxification pathways that clear out unnecessary thyroid hormone, when these get stuck in the body you can develop thyroid hormone resistance making cells lose their sensitivity to thyroid hormones.
* Weakens the immune barriers of the gut, lungs, and brain and weaken the immune system, in general.
When this happens, you can have more immune flare ups and this can trigger your Hashimoto’s and make it worse.
Here’s the tricky thing about adrenal stress: it’s almost always caused – at least in part – by something else.
These causes include anemia, blood sugar swings, gut inflammation, food intolerances (especially gluten, dairy and soy), essential fatty acid deficiencies, environmental toxins, and of course, chronic emotional and psychological stress.
Sound familiar?
These are also all the things that make Hashimoto’s worse.
We can’t ignore them or pretend like they aren’t there like so many doctors do. We have to deal with all of them.
Here’s the thing, we have maxed out our stress cards (like our credit cards for stress).
With Hashimoto’s your body is under so much physiological stress, all the time, that extra emotional stress will often totally wipe you out.
This happens because we’ve emptied our accounts and now we have to reinvent our lives and this means what you do everyday.
We have to start putting relaxation and fun back into our “stress savings” accounts.
Seriously, you have to replenish this account. It’s not enough to say “Yeah, I have nothing in that account.”
Because just like your bank account if you aren’t putting money back in and you’re always just taking money out, what happens?
Eventually, you go broke and you got all these creditors after you and lose your house and your car and eventually, you wind up on the street.
Talked about stressed out!
That’s what’s happening in your body. You wind up with the functional equivalent of being homeless inside your own body.
And, really, we have plenty of opportunities to take positive actions regarding stress every day, and often these wind up being missed opportunities and actually lead to more stress.
Here are 5 common mistakes people make every day dealing with stress.
The most important thing you can do is start becoming aware of this.
Are you…
1. Working through lunch (or other meals)?
This is a really common problem. many people don’t take the time to relax and enjoy their meals. This is a huge opportunity to relax and if you are stressed during your meal, it has a big impact on your digestion and absorption of food and vital nutrients.
2. Using your break time to vent and complain?
What you focus on is what becomes reality. Put that energy into manifesting something positive, like healing.
Go for a walk, appreciate the things around you instead.
3. Doing too many things at once?
Try slowing down and doing one thing at a time. So many people spend their days multi-tasking themselves into a totally stressed out state of mind (and body).
4. Not asking for help?
How often do we let our pride stop us from asking for help when we really need it? There’s no shame in admitting you need help and reaching out to someone and asking.
5. Denying there’s a problem?
So many people pretend they have stress under control when they really don’t, at all.
It is a very powerful trigger of autoimmunity. It can completely torpedo your progress.
You can’t just pretend it’s not here.
It’s here and it’s here to stay, so you need effective strategies for having less of it.
Every day.
Please share with us your best stress relieving practices.
In today’s health tip, I’d like to talk about remission from Hashimoto’s.
Remission should be the goal for all of us. We should all strive to get Hashimoto’s to a place that can allow us to have our lives back.
And we should all work hard to stop the progression and the proliferation of the underlying autoimmune process.
The stakes of not doing this are just too high.
But how do you define remission? And what happens when you get there?
The problem with focusing on this as a goal is that this implies that once we reach it, we’re done.
And this begs the question: How do we know when we get there?
One way that some people define remission is normal blood work including normal or undetectable antibodies.
There are several problems with this.
Many, many people have normal blood test results and feel awful.
And antibody numbers are not static, they are changing all the time. Getting them into a normal range is not a guarantee that they will stay there.
And there are lots of reasons why blood tests can look normal and you can still feel terrible. The immune system can release TSH and thyroid hormones all by itself, and this can throw off your results and make them less meaningful.
Also, your pituitary absorbs thyroid hormone differently than the cells in the rest of your body, so it may be getting enough thyroid hormone while the rest of your body is not.
Again making your blood test results less meaningful.
So, blood test results aren’t a great measure of success. As I have said repeatedly, how you feel, on the other hand, is diagnostically important and clinically relevant with Hashimoto’s.
This is actually a really important measure of success.
And the other problem with viewing remission as an end point is that if we do get there, it is a natural tendency to get complacent and to just go back to the same old behavior and diet that contributed to you being sick in the first place.
That’s just human nature.
So, I invite you to see remission as a journey and not as a destination. And to view it as a path and not a place you reach.
If you think about it his way, it involves a higher level of acceptance and commitment. Because it’s not conditional and it’s not something you’re ever finished with.
Remission is an ever evolving journey and if you are committed and vigilant and open to the possibilities of personal growth and transformation then it becomes like a kind of garden that just keeps rewarding you with new gifts.
Because here’s the other thing, you never know how good it could be and if you just settle for normal blood test results, then you might be putting a cap on this that stops you from going to a much higher place.
The possibilities are endless, people, when you think of it this way.
What we need to do is to create a lifestyle that supports healing and remission every single day. And strive to do that at every opportunity.
That’s a whole different ball game.
What are your thoughts on this? Please share them with us.
A recent study published in the the Journal of Interdisciplinary Toxicology (Vol. 6(4): 159–184. by Anthony Samsel and Stephanie Seneff looks at the health impact on glyphosates, the main ingredient in Monsanto’s marquee product Roundup.
This is a popular herbicide used for many purposes including domination of the world’s seed supply.
Here what they found.
This stuff is everywhere and it is used by farmers on wheat crops 2-3 days before harvesting to dry everything out and make it easier to harvest.
Why let it dry in the sun when you can spray it with toxic chemicals?
This is now also used on all grain crops, rice, seeds, dried beans and peas, sugar cane, sweet potatoes, and sugar beets.
It is also used on genetically modified crops like corn and soy, extensively.
Well, it turns out that glyphosate is a known endocrine disruptor, not good news for all us thyroid hormone fans and it has a lot of other really bad effects on our bodies.
Samsel & Seneff have carefully researched the known (published) effects of glyphosate along with the known (published) pathologies associated with celiac disease, gluten intolerance and irritable bowel syndrome.
They have identified chemical and biological pathways where glyphosate can be the cause.
These are: disruption of the gut bacteria; breakdown in the junctions of the intestinal wall; depletion of vital minerals, vitamins and nutrients; and impairment of cytochrome enzymes that aid the liver in detoxifying environmental toxins, thus multiplying the negative effect of other environmental toxins to which we are exposed in increasing amounts.
Translation: Glyphosate may lead to leaky gut, which allows glyphosate soaked gluten to get into your blood stream and your brain, where it does major damage.
This begs the question, is the problem gluten or Roundup?
The answer for you and me?
It doesn’t matter, because they are now one in the same. Go 100% gluten free people.
It’s just not worth the damage it causes.
http://sustainablepulse.com/wp-content/uploads/2014/02/Glyphosate_II_Samsel-Seneff.pdf
Hashimoments are affirmations and positive thoughts for people with Hashimoto’s. I started to write them because after reading research on the role of stress and emotions on the immune system, I realized how important what you think about and how you feel can be for your health.
I think one of the most challenging things about having Hashimoto’s is having to accept that there is no end point in dealing with this disease.
We can make tremendous progress in getting it under control or, hopefully, in remission. However, keeping it there requires daily commitment, discipline and vigilance.
And when you slip up, you pay.
And (forgive my language) sometimes the payment puts you on your ass and you are reminded, painfully, of what you can not do.
The point I’m trying to make is that this is a journey and while you make stops along the way, like any trip, you’ll never arrive at that place with no consequences.
Everything You Do Has Consequences
This is true of regular life, but it is especially true with Hashimoto’s.
What you do has special importance because of the challenges your body already faces.
What you eat, what you think, how much stress you have, what you drink, you name it, it all matters.
So, we’re faced with how we experience this.
It’s All About the Way You Look at It
Is it a crushing defeat or an incredible blessing?
This is the very definition of living in the moment.
This is what many saints and mystics strive for. Something to keep them present. What they often add is the element of detachment. That is their goal, to be present in every moment but to not be attached to that moment.
Be conscious of the decisions you make. Live in the now. Make those decisions count.
Because whether you like it or not, they will anyway.